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-Surgical resection: Surgical debulking reduces the
symptoms from mass effect and provides tissue for histologic diagnosis and
molecular studies. Malignant gliomas cannot be completely removed
surgically because of their infiltrative nature, but patients should
undergo maximal surgical resection whenever possible
-Radiotherapy: Conventional radiotherapy usually consists
of 60 Gy of partial-field external-beam irradiation delivered 5 days per
week in fractions of 1.8 to 2.0 Gy.
Recurrent tumors
Reoperation in selected patients, carmustine wafers
(Gliadel), conventional chemotherapy (e.g., lomustine, carmustine, PCV,
carboplatin, irinotecan, etoposide), bevacizumab plus irinotecan,
experimental therapies
Selected References:
Olson
et al, 2009 -
Kanu et al, 2009 -
Wen and
Kesari, 2008 -
Stupp
et al, 2005
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