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Brain Tumors Information for: - Physcicians - Researchers - Pacientes - Familiares Useful Information
Glioblastoma Multiforme
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GLIOBLASTOMA MULTIFORME (GBM) GBM is a glioma and the most common type of primary brain tumor. Gliomas are classified by the World Health Organization into 4 distinct grades based on histological features of cellularity, nuclear morphology, mitotic activity, necrosis, and vascular proliferation (Louis=et alK, 2007). A higher histologic grade corresponds to a less differentiated phenotype and to increasing malignancy. The most common form, a grade IV glioma, is called glioblastoma multiforme (GBM). Accounts for more than one half of all gliomas and 15% to 20% of intracranial tumors, GBM is the most common malignant primary brain tumor. It may occur at any age but most commonly affects adults, with a peak incidence between 45 and 70 years of age. GBMs usually occur within the subcortical white matter, where they may present de novo as a primary GBM or after dedifferentiation from lower-grade glioma (secondary). It is thought that 60% of these tumors are de novo in adults older than the age of 50 years. Secondary GBM typically develops in younger patients under the age of 45 years through malignant progression from a low-grade astrocytoma or AA. To read more about GBM, clik on the specific links (In Green) on the left. |
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