Glioblastoma in multiple sclerosis: a case report. Frisullo G, Patanella AK, Nociti V, Cianfoni A, Iorio R, Bianco A, Marti A, Tonali PA, Batocchi AP. J Neurooncol. 2009 Aug;94(1):141-4.

Department of Neuroscience, Institute of Neurology, Catholic University, Largo Agostino Gemelli, 8, Rome 00168, Italy.

Cerebral tumor and multiple sclerosis (MS) relapses can show overlapping clinical and magnetic resonance imaging features. In a previous study we observed in relapsing MS patients increased T-bet, pSTAT1, and pSTAT3 expressions in circulating mononuclear cells. During the data analysis we observed that T-bet, pSTAT1, and pSTAT3 expression was not increased in circulating mononuclear cells from a relapsing-remitting (RR)MS patient with recent onset of new neurological signs due to glioblastoma multiforme. In conclusion, our patient represents an exemplary case which suggests that T-bet, pSTAT1, and pSTAT3 expression in peripheral blood mononuclear cells (PBMCs) might be useful to differentiate MS relapses from other noninflammatory diseases.